ADMET predictions of pharmacokinetics properties from chemical composition in Plai (Zingiber cassumunar Roxb) oil

Sasipen  Krutchangthong; Pornnapa  Somkul; Pradapet  Krutchangthong; Chawalit  Yongram

Sasipen Krutchangthong Suan Sunandha Rajabhat University, Thailand
Pornnapa Somkul Suan Sunandha Rajabhat University, Thailand
Pradapet Krutchangthong Suan Sunandha Rajabhat University, Thailand
Chawalit Yongram Suan Sunandha Rajabhat University, Thailand

Keywords: Plai oil, ADMET, pharmacokinetics, GCMS

Abstract

Zingiber cassumunar Roxb. (Plai) is a medicinal plant in Thailand, the traditionally used to treat inflammation, pain, and respiratory problems. The Plai oil is a Thai traditional medicine for muscle relaxation. In this study, Plai oil was analyzed the chemical composition by GCMS technique and pharmacokinetics were predicted. The result showed that the 6 identified compounds which are menthol 42.71% followed by (+)-2-bornanone21.44%, endo-borneol 17.9%, isoborneol 8.3%, caryophyllene 0.99% and grandlure IV 0.48%, respectively. The pharmacokinetics predictions demonstrated a good physicochemical and pharmacokinetics properties than diclofenac, as a positive control. From the result, it was concluded that Plai oil has the potential to treat inflammation, pain and muscle relaxation based on ADMET prediction data.