BITTER BUSH, CHROMOLAENA ODORATA (L.) HAD BIOACTIVE METABOLITE AGAINST BACTERIAL PATHOGEN IN TILAPIA AND SHRIMP.
Bitter bush or Siam weed had the specific name is Chromolaena odorata (L.) R.M. King & H. Rob the classified in order Asterales and family Asteraceae. The plant grows best in sunny or open areas such as roadsides, abandoned fields, pastures, and disturbed forests, but tolerates semi-shade conditions. A single shrub can produce as many as 80,000 seeds in dry season. The species has the tenacity to invade human-induced disturbed and undisturbed lands, posing a significant economic and ecological burden in many countries in its in-troduced ranges. The unique aroma odour and may poisonous toxic for cattle stomach that the advantage gave the bioactive metabolite against various aquatic infectious microorganisms including Streptococcus agalactiae (2809) in bighead carp and tilapia infection and Vibrio parahaemolyticus (NX89) and V. parahaemolyticus (5HP) in that cause the Acute Hepatopancreatic Necrosis Disease (AHPND), or Early Mortality Syndrome (EMS), in shrimp infection. Isopropanol was the appropriated solvent found antimicrobial screening performance and Its metabolite extraction could beneficial for aquatic treatment on further.